Abstract | BACKGROUND: METHODS: RESULTS: The two drugs were equianalgesic with similar potency values ( oliceridine: 27.9 ± 4.9 ng/ml; morphine 34.3 ± 9.7 ng/ml; potency ratio, 0.81; 95% CI, 0.39 to 1.56). A 50% reduction of the hypercapnic ventilatory response by morphine occurred at an effect-site concentration of 33.7 ± 4.8 ng/ml, while a 25% reduction by oliceridine occurred at 27.4 ± 3.5 ng/ml (potency ratio, 2.48; 95% CI, 1.65 to 3.72; P < 0.01). Over the clinically relevant concentration range of 0 to 35 ng/ml, the oliceridine utility function was positive, indicating that the probability of analgesia exceeds the probability of respiratory depression. In contrast, the morphine function was negative, indicative of a greater probability of respiratory depression than analgesia. CONCLUSIONS:
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Authors | Albert Dahan, C Jan van Dam, Marieke Niesters, Monique van Velzen, Michael J Fossler, Mark A Demitrack, Erik Olofsen |
Journal | Anesthesiology
(Anesthesiology)
Vol. 133
Issue 3
Pg. 559-568
(09 2020)
ISSN: 1528-1175 [Electronic] United States |
PMID | 32788558
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- ((3-methoxythiophen-2-yl)methyl)((2-(9-(pyridin-2-yl)-6-oxaspiro(4.5)decan-9-yl)ethyl))amine
- Analgesics, Opioid
- Spiro Compounds
- Thiophenes
- Morphine
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Topics |
- Adult
- Analgesics, Opioid
(adverse effects, pharmacology)
- Healthy Volunteers
- Humans
- Male
- Middle Aged
- Morphine
(adverse effects, pharmacology)
- Reference Values
- Respiratory Insufficiency
(chemically induced)
- Risk Assessment
- Spiro Compounds
(adverse effects, pharmacology)
- Thiophenes
(adverse effects, pharmacology)
- Young Adult
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