Abstract | INTRODUCTION: A new treatment strategy involving cytoreductive surgery (CRS) combined with perioperative intraperitoneal (IP) chemotherapy was proposed in 1999 by the Peritoneal Surface Oncology Group International, and the strategy is now justified as a state-of-the-art treatment to improve the long-term survival of patients with peritoneal metastasis (PM). To achieve cure in the patients with PM, complete removal of macroscopic tumors and eradication of micrometastasis on the peritoneum, left after CRS are essential. Systemic chemotherapy is not indicated for the treatment of PM. In contrast, intraperitoneal (IP) chemotherapy brings about significantly higher locoregional dose intensity in the peritoneal cavity and subperitoneal tissues. In combination with anticancer drugs, hyperthermia enhances cytotoxicity against cancer cells. AREA COVERED: EXPERT OPINION: CRS plus perioperative intraperitoneal chemotherapy is safe with acceptable morbidity and mortality. It is justified as a standard treatment to improve the long-term survival of patients with PM and is now performed with curative intent for PM from various malignancies.
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Authors | Yutaka Yonemura, Haruaki Iahibashi, Shouzou Sako, Akiyoshi Mizumoto, Nobuyuki Takao, Masumi Ichinose, Shunsuke Motoi, Yang Liu, Satoshi Wakama, Yasuyuki Kamada, Kazurou Nishihara |
Journal | Expert opinion on pharmacotherapy
(Expert Opin Pharmacother)
Vol. 21
Issue 16
Pg. 2057-2066
(Nov 2020)
ISSN: 1744-7666 [Electronic] England |
PMID | 32783786
(Publication Type: Journal Article, Systematic Review)
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Chemical References |
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Topics |
- Antineoplastic Agents
(administration & dosage, pharmacokinetics, therapeutic use)
- Chemotherapy, Cancer, Regional Perfusion
(methods)
- Clinical Trials as Topic
- Combined Modality Therapy
- Cytoreduction Surgical Procedures
(methods)
- Female
- Humans
- Hyperthermia, Induced
(methods)
- Peritoneal Neoplasms
(drug therapy, mortality, secondary, surgery)
- Peritoneum
(pathology, surgery)
- Survival Analysis
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