The influence of seasonal factors on the incidence of peritoneal dialysis-associated peritonitis.

Abstract

OBJECTIVES:

To investigate the effects of climatic variables on peritoneal dialysis-associated peritonitis (PDAP) among patients receiving PD, such as seasonal variations in temperature and humidity.

METHODS:

A retrospective analysis was performed on PD patients, from 1 January 2011, to 31 December 2019. We evaluated the influence of seasonal factors on peritonitis rates and outcomes.

RESULTS:

Over the 9-year study period, 667 peritonitis episodes occurred, in 401 PD patients. Diarrhea-associated peritonitis occurred more frequently in summer compared with other seasons. Eating raw and cold food was identified as the primary cause of peritonitis in the summer. More peritonitis episodes occurred during summer. The peritonitis rate associated with gram-negative bacteria (p = 0.050) during summer was higher than those in all other seasons. The gram-negative bacterial peritonitis rate was positively correlated with monthly mean temperature (r = 0.504, p < 0.01) and humidity (r = 0.561, p < 0.01). A similar trend was observed for Enterobacterial peritonitis (temperature: r = 0.518, p < 0.01; humidity: r = 0.456, p = 0.001). Logistic regression analysis showed that summer was a risk factor for peritonitis (p = 0.041). Peritonitis prognosis during summer was significantly worse than those for all other seasons (p = 0.037).

CONCLUSIONS:

Seasonal variations exist in the incidence of dialysis-associated peritonitis, with peak incidents caused by gram-negative bacteria in the summer. High average temperature and humidity are associated with significant increases in the gram-negative bacteria and Enterobacterial peritonitis rates. Peritonitis prognosis during summer is worse.

• Authors: Ying Zeng, Xiaomei Jiang, Sheng Feng, Linsen Jiang, Zhi Wang, Huaying Shen, Shan Jiang
• Journal: Renal failure (Ren Fail) Vol. 42 Issue 1 Pg. 807-817 (Nov 2020) ISSN: 1525-6049 [Electronic] England
• PMID: 32781861 (Publication Type: Journal Article)

Chemical References

• Anti-Bacterial Agents

Topics

• Adult
• Aged
• Anti-Bacterial Agents (therapeutic use)
• China (epidemiology)
• Enterobacteriaceae Infections (epidemiology, etiology)
• Female
• Gram-Negative Bacterial Infections (epidemiology, etiology)
• Humans
• Incidence
• Kidney Failure, Chronic (epidemiology, therapy)
• Logistic Models
• Male
• Middle Aged
• Multivariate Analysis
• Peritoneal Dialysis (adverse effects)
• Peritonitis (epidemiology, etiology)
• Retrospective Studies
• Seasons