The role of mitochondrial ATP synthase in cancer.

Abstract

The mitochondrial ATP synthase is a multi-subunit enzyme complex located in the inner mitochondrial membrane which is essential for oxidative phosphorylation under physiological conditions. In this review, we analyse the enzyme functions involved in cancer progression by dissecting specific conditions in which ATP synthase contributes to cancer development or metastasis. Moreover, we propose the role of ATP synthase in the formation of the permeability transition pore (PTP) as an additional mechanism which controls tumour cell death. We further describe transcriptional and translational modifications of the enzyme subunits and of the inhibitor protein IF1 that may promote adaptations leading to cancer metabolism. Finally, we outline ATP synthase gene mutations and epigenetic modifications associated with cancer development or drug resistance, with the aim of highlighting this enzyme complex as a potential novel target for future anti-cancer therapy.

• Authors: Chiara Galber, Manuel Jesus Acosta, Giovanni Minervini, Valentina Giorgio
• Journal: Biological chemistry (Biol Chem) Vol. 401 Issue 11 Pg. 1199-1214 (10 25 2020) ISSN: 1437-4315 [Electronic] Germany
• PMID: 32769215 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)

Chemical References

• ATPase inhibitory protein
• Mitochondrial Permeability Transition Pore
• Protein Subunits
• Proteins
• Mitochondrial Proton-Translocating ATPases

Topics

• Animals
• Gene Expression Regulation, Neoplastic
• Humans
• Mitochondria (genetics, metabolism, pathology)
• Mitochondrial Permeability Transition Pore (analysis, metabolism)
• Mitochondrial Proton-Translocating ATPases (analysis, genetics, metabolism)
• Mutation
• Neoplasms (genetics, metabolism, pathology)
• Protein Modification, Translational
• Protein Subunits (analysis, genetics, metabolism)
• Proteins (analysis, metabolism)