The pathogenesis of bullous skin diseases.

Abstract

Bullous skin diseases are a group of dermatoses characterized by blisters and bullae in the skin and mucous membranes. The etiology and pathogenesis of bullous skin diseases are not completely clear. The most common are pemphigus and bullous pemphigoid (BP). Autoantibodies play critical roles in their pathogenesis. Abnormalities in the adhesion between keratinocytes in patients with pemphigus leads to acantholysis and formation of intra-epidermal blisters. Anti-desmoglein autoantibodies are present both in the circulation and skin lesions of patients with pemphigus. The deficient adhesion of keratinocytes to the basement membrane in BP patients gives rise to subepidermal blisters. Autoantibodies against the components of hemidesmosome can be detected in BP patients. Many novel therapeutics based on knowledge of the pathogenesis have emerged in recent years.

• Authors: Miao Yang, Haijing Wu, Ming Zhao, Christopher Chang, Qianjin Lu
• Journal: Journal of translational autoimmunity (J Transl Autoimmun) Vol. 2 Pg. 100014 (Dec 2019) ISSN: 2589-9090 [Electronic] Netherlands
• PMID: 32743502 (Publication Type: Journal Article, Review)
• Copyright: © 2019 The Authors.