Investigating the effects of walnut ointment on non-healing burn wounds.

Abstract

Effective treatments for non-healing burn wounds are an unmet need for 95% of burn sufferers. Approaches currently available to treat non-healing burn wounds are not satisfactory due to undesirable side-effects or expense. The anti-oxidation and antibacterial activities of walnuts are recommended for treating chronic diseases. Walnut ointment has been developed and successfully applied to treat non-healing burn wounds in our hospital for decades. We report herein a detailed retrospective case review examining patients' response to the walnut ointment. The walnut ointment has shortened healing time of non-healing burn wounds and improved clinical outcomes. In order to investigate the mechanism of action, walnut ointment has been applied on wounds of porcine full-thickness burn wound models. Histological and immunohistochemical analysis indicated our walnut ointment supports wound healing through promoting keratinocyte proliferation and differentiation. Taken together, we recommend the walnut ointment offers an effective and economical treatment for patients presenting with non-healing burn wounds.

• Authors: Qian Chen, Xingwang Deng, Lijuan Qiang, Ming Yao, Lifeng Guan, Nan Xie, Dan Zhao, Jiaxiang Ma, Liqiong Ma, Yinsheng Wu, Xie Yan
• Journal: Burns : journal of the International Society for Burn Injuries (Burns) Vol. 47 Issue 2 Pg. 455-465 (03 2021) ISSN: 1879-1409 [Electronic] Netherlands
• PMID: 32736884 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2020 Elsevier Ltd and ISBI. All rights reserved.

Chemical References

• Emollients
• Ointments

Topics

• Animals
• Burns (drug therapy)
• Emollients
• Humans
• Juglans
• Ointments
• Retrospective Studies
• Swine
• Wound Healing