Lysine-specific histone demethylase 1A (LSD1) in cervical cancer.

Abstract

PURPOSE:

Demethylation of DNA through enzymes like LSD1 showed a crucial impact on different kind of cancers. Epigenetic modifications in cervical cancer are still not fully investigated nevertheless of high interest for a therapeutic use.

METHODS:

Tumor samples of 250 cervical cancer patients were immunochemically stained and evaluated based on Immunoreactive Score. Results were statistically analyzed for clinical and pathological parameters.

RESULTS:

Our patient collective showed a disadvantage for 10-year survival for patients with a strong expression of LSD1 in the cytoplasm of cervical cancer cells. The results of the correlational analysis further revealed a negative correlation of LSD1 to G-protein coupled estrogen receptor (GPER).

CONCLUSIONS:

Epigenetic changes through enzymes like LSD1 may also be of interest for patients with cervical cancer. A combined therapy with other proteins relayed to cervical cancer like GPER might be of interest for future investigations.

• Authors: Daniel Beilner, Christina Kuhn, Bernd P Kost, Julia Jückstock, Doris Mayr, Elisa Schmoeckel, Christian Dannecker, Sven Mahner, Udo Jeschke, Helene Hildegard Heidegger
• Journal: Journal of cancer research and clinical oncology (J Cancer Res Clin Oncol) Vol. 146 Issue 11 Pg. 2843-2850 (Nov 2020) ISSN: 1432-1335 [Electronic] Germany
• PMID: 32725356 (Publication Type: Journal Article)

Chemical References

• Biomarkers, Tumor
• Histone Demethylases
• KDM1A protein, human

Topics

• Adenocarcinoma (enzymology, pathology)
• Adult
• Aged
• Aged, 80 and over
• Biomarkers, Tumor (analysis)
• Carcinoma, Squamous Cell (enzymology, pathology)
• Female
• Histone Demethylases (analysis, metabolism)
• Humans
• Middle Aged
• Uterine Cervical Neoplasms (enzymology, pathology)