Abstract | BACKGROUND: OBJECTIVE: METHODS: Two hundred and four women donated sera to the Janus Serum Bank in Norway pre- and post-diagnosis of ovarian cancer, donations separated by approximately 14 years. We measured calcium and albumin in these sera and calculated the albumin-corrected calcium. Sera were adjusted for patient age and storage time. RESULTS: Post-diagnosis, mean age- and storage-adjusted calcium increased, from 2.53 to 2.68 mmol/L (p < .001). Mean age- and storage-adjusted, albumin-corrected calcium increased from 2.3 to 2.7 mmol/L (p < .001). Conversely, mean age- and storage-adjusted albumin decreased, from a mean of 51.3 to 40.9 g/L (p < .001). Significant changes were observed in women with early stage and metastatic cancer. CONCLUSIONS:
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Authors | Gary G Schwartz, Steinar Tretli, Marilyn G Klug, Trude E Robsahm |
Journal | Gynecologic oncology
(Gynecol Oncol)
Vol. 159
Issue 1
Pg. 264-269
(10 2020)
ISSN: 1095-6859 [Electronic] United States |
PMID | 32723677
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2020 The Authors. Published by Elsevier Inc. All rights reserved. |
Chemical References |
- Biomarkers, Tumor
- Calcium
- Serum Albumin, Human
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Topics |
- Adult
- Biomarkers, Tumor
(blood)
- Calcium
(blood)
- Early Detection of Cancer
(methods)
- Feasibility Studies
- Female
- Humans
- Longitudinal Studies
- Middle Aged
- Norway
- Ovarian Neoplasms
(blood, diagnosis)
- Prognosis
- Serum Albumin, Human
(analysis)
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