Abstract | BACKGROUND: The effect of nonnutritive sweeteners on appetite is controversial. Some studies have found changes in certain appetite control hormones with sucralose intake that may be through interaction with sweet taste receptors located in the intestine. OBJECTIVE: DESIGN: A 2-week parallel randomized clinical trial with an additional visit conducted 1 week after dosing termination. PARTICIPANTS/SETTING: Sixty healthy, normal-weight individuals, without habitual consumption of nonnutritive sweeteners were recruited from July 2015 to March 2017 in Mexico City. INTERVENTION: Daily sucralose consumption at 15% of the acceptable daily intake by using commercial sachets added to food. The control group followed the same protocol without an intervention. MAIN OUTCOMES MEASURED: STATISTICAL ANALYSIS PERFORMED: Basal and final concentrations were compared using Wilcoxon matched-pairs test and Mann-Whitney U test for analysis between groups. Repeated measures analysis of variance was used to evaluate changes in the homeostasis model assessment of insulin resistance. RESULTS:
Sucralose was not associated with changes in any of the hormones measured. One week postintervention, an incremental change (P=0.04) in the homeostasis model assessment of insulin resistance was found in the intervention group. CONCLUSIONS:
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Authors | Alonso Romo-Romo, Carlos A Aguilar-Salinas, M Guadalupe López-Carrasco, Luz E Guillén-Pineda, Griselda X Brito-Córdova, Rita A Gómez-Díaz, Francisco J Gómez-Pérez, Paloma Almeda-Valdes |
Journal | Journal of the Academy of Nutrition and Dietetics
(J Acad Nutr Diet)
Vol. 120
Issue 8
Pg. 1295-1304
(08 2020)
ISSN: 2212-2672 [Print] United States |
PMID | 32711853
(Publication Type: Journal Article, Randomized Controlled Trial)
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Copyright | Copyright © 2020 Academy of Nutrition and Dietetics. Published by Elsevier Inc. All rights reserved. |
Chemical References |
- Blood Glucose
- Dipeptides
- Ghrelin
- Insulin
- Leptin
- tyrosyltyrosine
- Sucrose
- Glucagon-Like Peptide 1
- trichlorosucrose
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Topics |
- Adult
- Appetite
(drug effects)
- Blood Glucose
(analysis)
- Diet
- Dipeptides
(blood)
- Fasting
- Female
- Ghrelin
(blood)
- Glucagon-Like Peptide 1
(blood)
- Humans
- Insulin
(blood)
- Insulin Resistance
- Leptin
(blood)
- Male
- Mexico
- Sucrose
(administration & dosage, analogs & derivatives)
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