Evolving roles of lysyl oxidase family in tumorigenesis and cancer therapy.

Abstract

The lysyl oxidase (LOX) family is comprised of LOX and four LOX-like proteins (LOXL1, LOXL2, LOXL3, and LOXL4), and mainly functions in the remodeling of extracellular matrix (ECM) and the cross-linking of collagen and elastic fibers. Recently, a growing body of research has demonstrated that LOX family is critically involved in the regulation of cancer cell proliferation, migration, invasion and metastasis. In this review, we discuss the roles of LOX family members in the development and progression of different types of human cancers. Furthermore, we also describe the potential inhibitors of LOX family proteins and highlight that LOX family might be an important therapeutic target for cancer therapy.

• Authors: Miaomiao Ye, Yizuo Song, Shuya Pan, Man Chu, Zhi-Wei Wang, Xueqiong Zhu
• Journal: Pharmacology & therapeutics (Pharmacol Ther) Vol. 215 Pg. 107633 (11 2020) ISSN: 1879-016X [Electronic] England
• PMID: 32693113 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
• Copyright: Copyright © 2020 Elsevier Inc. All rights reserved.

Chemical References

• Amino Acid Oxidoreductases
• Protein-Lysine 6-Oxidase

Topics

• Amino Acid Oxidoreductases (antagonists & inhibitors, metabolism)
• Animals
• Carcinogenesis
• Disease Progression
• Extracellular Matrix (metabolism)
• Humans
• Molecular Targeted Therapy
• Neoplasms (enzymology, pathology, therapy)
• Protein-Lysine 6-Oxidase (antagonists & inhibitors, metabolism)