From Seeds of Apium graveolens Linn. to a Cerebral Ischemia Medicine: The Long Journey of 3-n-Butylphthalide.

Abstract

3-n-Butylphthalide (NBP) as well as its derivatives and analogues (NBPs), in racemic or enantiomerically pure forms, possess potent and diverse pharmacological properties and have shown a great potential therapeutic interest for many human conditions, especially for cerebral ischemia. This Perspective outlines the synthesis and therapeutic applications of NBPs.

• Authors: José Marco-Contelles, Yihua Zhang
• Journal: Journal of medicinal chemistry (J Med Chem) Vol. 63 Issue 21 Pg. 12485-12510 (11 12 2020) ISSN: 1520-4804 [Electronic] United States
• PMID: 32672958 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Benzofurans
• Neuroprotective Agents
• 3-n-butylphthalide

Topics

• Animals
• Apium (chemistry, metabolism)
• Asthma (drug therapy, pathology)
• Benzofurans (chemical synthesis, chemistry, therapeutic use)
• Brain Ischemia (drug therapy, pathology)
• Humans
• Neuroprotective Agents (chemical synthesis, chemistry, therapeutic use)
• Seeds (chemistry, metabolism)
• Stereoisomerism
• Stroke (drug therapy, pathology)