Abstract | BACKGROUND: Previous studies have suggested a significant relationship between hyposalivation and inhalation therapy-induced oropharyngeal problems. However, salivary secretion tests are not widely performed in daily clinical practice. In fact, xerostomia, the complaint of dry mouth, may not indicate hyposalivation. Therefore, we determined the clinical factors associated with hyposalivation in patients with asthma. METHODS: This study is a post-hoc analysis of our previous studies. Adult patients with asthma on maintenance inhalation therapy were enrolled. The participants completed questionnaires on oropharyngeal symptoms and underwent a salivary secretion test. Symptom severity was evaluated using a numerical rating scale (NRS), and salivary secretion was measured using the modified cotton roll method. Using logistic regression analysis, we identified the clinical factors associated with hyposalivation. RESULTS: In total, 531 patients completed the questionnaire (43.8 ± 16.9 years and male/female = 171/360), and 234 patients successfully performed a salivary secretion test, of which 126 (53.8%) were diagnosed with hyposalivation (<0.25 g/min). The patients with hyposalivation were significantly older (p < 0.0001) and had severe xerostomia and/or gastroesophageal reflux-like symptoms (GERLS) (p < 0.0001). Many of these patients had also used inhaled long-acting beta agonists (p = 0.012) and high-dose inhaled corticosteroids (p = 0.024). Multivariate analysis revealed that advanced age (odds ratio [OR] 1.05, p < 0.0001), severe xerostomia (OR 1.02, p = 0.0006) and severe GERLS (OR 1.02, p = 0.001) were independently and significantly associated with hyposalivation. CONCLUSIONS:
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Authors | Setsuko Koshiyama, Kazuya Tanimura, Kayoko Ito, Saori Funayama, Daiki Hira, Yuko Komase, Susumu Sato |
Journal | Respiratory investigation
(Respir Investig)
Vol. 59
Issue 1
Pg. 114-119
(Jan 2021)
ISSN: 2212-5353 [Electronic] Netherlands |
PMID | 32665193
(Publication Type: Journal Article)
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Copyright | Copyright © 2020 The Japanese Respiratory Society. Published by Elsevier B.V. All rights reserved. |
Chemical References |
- Adrenal Cortex Hormones
- Adrenergic beta-Agonists
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Topics |
- Administration, Inhalation
- Adrenal Cortex Hormones
(administration & dosage, adverse effects)
- Adrenergic beta-Agonists
(administration & dosage, adverse effects)
- Adult
- Age Factors
- Asthma
(complications, drug therapy)
- Female
- Gastroesophageal Reflux
(etiology)
- Humans
- Maintenance Chemotherapy
(adverse effects)
- Male
- Middle Aged
- Severity of Illness Index
- Surveys and Questionnaires
- Xerostomia
(diagnosis, etiology)
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