Intraabdominal urokinase in the treatment of loculated infected ascites in cirrhosis.

Abstract

Cirrhotic patients may present loculated ascites. We report a case of a 49-years old patient with cirrhosis and loculated infected ascites. Conventional and ultrasound (US)-guided paracentesis were ineffective. Moreover, US-guided drainages with 10 F drains could drain only small quantities of ascites localized in the largest loculated areas. Despite an adapted and long antibiotic therapy, the infection persisted. Intraabdominal fibrinolysis allowed the destruction of the fibrin septa, a better drainage and the sterilization of the ascites fluid. This is the first case report of effective intraabdominal fibrinolysis with urokinase in difficult to treat loculated infected ascites.

• Authors: Simona Tripon, Pierre Mayer, Axenia Svab, François Habersetzer, Patrick Pessaux, Thomas F Baumert, Iulian Enescu
• Journal: Clinics and research in hepatology and gastroenterology (Clin Res Hepatol Gastroenterol) Vol. 45 Issue 2 Pg. 101486 (Mar 2021) ISSN: 2210-741X [Electronic] France
• PMID: 32654936 (Publication Type: Case Reports)
• Copyright: Copyright © 2020. Published by Elsevier Masson SAS.

Chemical References

• Urokinase-Type Plasminogen Activator

Topics

• Ascites (etiology, therapy)
• Ascitic Fluid
• Humans
• Liver Cirrhosis (complications)
• Middle Aged
• Paracentesis
• Urokinase-Type Plasminogen Activator