Abstract | OBJECTIVE: MATERIAL AND METHODS: Full-mouth periodontal status together with unstimulated whole saliva and serum samples was collected from 78 individuals, including 40 periodontitis patients (20 smokers and 20 nonsmokers) and 38 periodontally healthy controls (20 smokers and 18 nonsmokers). The Luminex®-xMAP™ technique was used for protein analyses. RESULTS: Concentrations of all tested proteins in saliva as well as VEGF in serum were significantly higher in periodontitis patients than in healthy controls. In smokers, serum concentrations of endoglin (p = 0.017) and sICAM-1 (p = 0.001) were elevated in comparison to nonsmokers. After adjusting for smoking and gender, periodontitis associated significantly with salivary concentrations of b-FGF, PECAM-1, VEGF, sICAM-1, and sVCAM-1 (p < 0.01). CONCLUSION: Taken together, salivary concentrations of b-FGF, PECAM-1, and VEGF associate with periodontitis. The suppressive effect of smoking on salivary marker levels is limited to periodontitis patients only. CLINICAL RELEVANCE: Smoking-related suppression of salivary marker levels is observed only in periodontitis patients.
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Authors | Çiğdem Yılmaz Şaştım, Mervi Gürsoy, Eija Könönen, Akseli Kasurinen, Susanna Norvio, Ulvi Kahraman Gürsoy, Başak Doğan |
Journal | Clinical oral investigations
(Clin Oral Investig)
Vol. 25
Issue 3
Pg. 1117-1126
(Mar 2021)
ISSN: 1436-3771 [Electronic] Germany |
PMID | 32643086
(Publication Type: Journal Article)
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Chemical References |
- Biomarkers
- Vascular Endothelial Growth Factor A
- Intercellular Adhesion Molecule-1
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Topics |
- Biomarkers
- Humans
- Intercellular Adhesion Molecule-1
- Periodontitis
- Saliva
- Smoking
- Vascular Endothelial Growth Factor A
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