MSX1-A Potential Marker for Uterus-Preserving Therapy of Endometrial Carcinomas.

Abstract

Prognostic factors are of great interest in patients with endometrial cancer. One potential factor could be the protein MSX1, a transcription repressor, that has an inhibitory effect on the cell cycle. For this study, endometrioid endometrial carcinomas (n = 53), clear cell endometrial carcinomas (n = 6), endometrioid ovarian carcinomas (n = 19), and clear cell ovarian carcinomas (n = 11) were immunochemically stained for the protein MSX1 and evaluated using the immunoreactive score (IRS). A significant stronger expression of MSX1 was found in endometrioid endometrial carcinomas (p < 0.001), in grading 2 (moderate differentiation) (p = 0.001), and in tumor material of patients with no involvement of lymph nodes (p = 0.031). Correlations were found between MSX1 expression and the expression of β-Catenin, p21, p53, and the steroid receptors ERα, ERβ, PRα, and PRβ. A significant (p = 0.023) better survival for patients with an MSX1 expression in more than 10% of the tumor cells was observed for endometrioid endometrial carcinomas (21.3 years median survival (MSX1-positive) versus 17.3 years (MSX1-negative)). Although there is evidence that MSX1 expression correlates with improved long-term survival, further studies are necessary to evaluate if MSX1 can be used as a prognostic marker.

• Authors: Simon Eppich, Christina Kuhn, Elisa Schmoeckel, Doris Mayr, Sven Mahner, Udo Jeschke, Julia Gallwas, Helene Hildegard Heidegger
• Journal: International journal of molecular sciences (Int J Mol Sci) Vol. 21 Issue 12 (Jun 25 2020) ISSN: 1422-0067 [Electronic] Switzerland
• PMID: 32630554 (Publication Type: Journal Article)

Chemical References

• Biomarkers, Tumor
• MSX1 Transcription Factor
• MSX1 protein, human
• Transcription Factors
• Tumor Suppressor Protein p53

Topics

• Adenocarcinoma, Clear Cell (metabolism, pathology)
• Adult
• Aged
• Aged, 80 and over
• Biomarkers, Tumor (metabolism)
• Carcinoma, Endometrioid (metabolism, pathology)
• DNA Methylation (genetics)
• Endometrial Neoplasms (genetics, metabolism, pathology)
• Female
• Humans
• MSX1 Transcription Factor (genetics, metabolism, physiology)
• Middle Aged
• Ovarian Neoplasms (metabolism, pathology)
• Transcription Factors (metabolism)
• Tumor Suppressor Protein p53 (metabolism)
• Uterine Neoplasms (pathology)
• Uterus (metabolism, pathology)