A systematic review and meta-analysis of published cases reveals the natural disease history in multiple sulfatase deficiency.

Abstract

Multiple Sulfatase Deficiency (MSD, MIM#272200) is an ultra-rare lysosomal storage disorder arising from mutations in the SUMF1 gene, which encodes the formylglycine-generating enzyme (FGE). FGE is necessary for the activation of sulfatases, a family of enzymes that are involved in the degradation of sulfated substrates such as glycosaminoglycans and sulfolipids. SUMF1 mutations lead to functionally impaired FGE and individuals with MSD demonstrate clinical signs of single sulfatase deficiencies, including metachromatic leukodystrophy (MLD) and several mucopolysaccharidosis (MPS) subtypes. Comprehensive information related to the natural history of MSD is missing. We completed a systematic literature review and a meta-analysis on data from published cases reporting on MSD. As available from these reports, we extracted clinical, genetic, biochemical, and brain imaging information. We identified 75 publications with data on 143 MSD patients with a total of 53 unique SUMF1 mutations. The mean survival was 13 years (95% CI 9.8-16.2 years). Seventy-five clinical signs and 11 key clusters of signs were identified. The most frequently affected organs systems were the nervous, skeletal, and integumentary systems. The most frequent MRI features were abnormal myelination and cerebral atrophy. Individuals with later onset MSD signs and survived longer than those with signs at birth. Less severe mutations, low disease burden and achievement of independent walking positively correlated with longer survival. Despite the limitations of our approach, we were able to define clinical characteristics and disease outcomes in MSD. This work will provide the foundation of natural disease history data needed for future clinical trial design.

• Authors: Lars Schlotawa, Joana Preiskorn, Rebecca Ahrens-Nicklas, Stina Schiller, Laura A Adang, Jutta Gärtner, Tim Friede
• Journal: Journal of inherited metabolic disease (J Inherit Metab Dis) Vol. 43 Issue 6 Pg. 1288-1297 (11 2020) ISSN: 1573-2665 [Electronic] United States
• PMID: 32621519 (Publication Type: Journal Article, Meta-Analysis, Research Support, Non-U.S. Gov't, Systematic Review)
• Copyright: © 2020 The Authors. Journal of Inherited Metabolic Disease published by John Wiley & Sons Ltd on behalf of SSIEM.

Chemical References

• N-formylglycine
• Oxidoreductases Acting on Sulfur Group Donors
• SUMF1 protein, human
• Sulfatases
• Glycine

Topics

• Glycine (analogs & derivatives, genetics, metabolism)
• Humans
• Leukodystrophy, Metachromatic (genetics, pathology)
• Mucopolysaccharidoses (genetics, pathology)
• Multiple Sulfatase Deficiency Disease (genetics, pathology)
• Oxidoreductases Acting on Sulfur Group Donors (genetics)
• Protein Processing, Post-Translational (genetics)
• Sulfatases (deficiency, genetics)