N-formylglycine

A compound resulting from the condensation of glycine and formic acid with the formation of an amide bond. In most chemical sources "formylglycine" is used as a synonym for N-formylglycine. However, the active site of sulfatase enzymes, C(alpha)-formylglycine, may also be referred to as formylglycine.

Also Known As:

Networked: 19 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Dierks, Thomas: 5 articles (09/2013 - 05/2005)
2.	Gärtner, Jutta: 4 articles (11/2020 - 01/2008)
3.	Schlotawa, Lars: 4 articles (11/2020 - 01/2008)
4.	Schmidt, Bernhard: 3 articles (09/2013 - 05/2005)
5.	Ballabio, Andrea: 2 articles (12/2014 - 05/2007)
6.	Pepe, Stefano: 2 articles (12/2014 - 05/2007)
7.	Radhakrishnan, Karthikeyan: 2 articles (09/2013 - 03/2011)
8.	von Figura, Kurt: 2 articles (01/2008 - 05/2005)
9.	Hirai, Yukihiko: 2 articles (01/2007 - 08/2005)
10.	Hisayasu, Sanae: 2 articles (01/2007 - 08/2005)

Related Diseases

1.	Multiple Sulfatase Deficiency Disease (Mucosulfatidosis) 01/01/2023 - "Multiple sulfatase deficiency (MSD, MIM #272200) results from pathogenic variants in the SUMF1 gene that impair proper function of the formylglycine-generating enzyme (FGE). " 11/01/2020 - "Multiple Sulfatase Deficiency (MSD, MIM#272200) is an ultra-rare lysosomal storage disorder arising from mutations in the SUMF1 gene, which encodes the formylglycine-generating enzyme (FGE). " 10/01/2018 - "The major candidate for multiple sulfatase deficiency is a defective formylglycine-generating enzyme (FGE). " 10/01/2018 - "Structural distortions due to missense mutations in human formylglycine-generating enzyme leading to multiple sulfatase deficiency." 09/01/2013 - "Rapid degradation of an active formylglycine generating enzyme variant leads to a late infantile severe form of multiple sulfatase deficiency."
2.	Lysosomal Storage Diseases (Lysosomal Storage Disease) 03/01/2021 - "Multiple sulfatase deficiency (MSD) is a lysosomal storage disease caused by a deficiency of formylglycine-generating enzyme due to SUMF1 defects. " 10/23/2023 - "All sulfatases are post-translationally activated by the formylglycine generating enzyme (FGE) which is deficient in multiple sulfatase deficiency (MSD), a neurodegenerative lysosomal storage disease. "
3.	Metachromatic Leukodystrophy (Sulfatide Lipidosis) 08/01/2005 - "Coexpression of formylglycine-generating enzyme is essential for synthesis and secretion of functional arylsulfatase A in a mouse model of metachromatic leukodystrophy." 01/01/2007 - "AAV1 mediated co-expression of formylglycine-generating enzyme and arylsulfatase a efficiently corrects sulfatide storage in a mouse model of metachromatic leukodystrophy."
4.	Starvation 09/01/1977 - "Measurements of N-formylglycine amide ribonucleotide synthesis showed that lethality is a manifestation of purine starvation. "
5.	Fibrosis (Cirrhosis) 03/15/2023 - "In further, the panel of N-formylglycine, heptaethylene glycol and citrulline can more effectively discriminate early stage HCC from cirrhosis than AFP (AUC: 0.835 vs. 0.634). " 03/15/2023 - "Multivariate logistic regression analysis of candidate metabolites in validation cohort showed that N-formylglycine, oxoglutaric acid, citrulline and heptaethylene glycol could distinguish HCC from cirrhosis. "

Related Drugs and Biologics

1.	Enzymes
2.	Sulfatases
3.	Sulfoglycosphingolipids (Sulfatides)
4.	Ribonucleotides
5.	Cerebroside-Sulfatase (Arylsulfatase A)
6.	Amides
7.	Suspensions
8.	Sulfates (Sulfates, Inorganic)
9.	Steroids
10.	Sphingolipids