Abstract | OBJECTIVES: MATERIALS AND METHODS: Surgically resected OSCC with pathologically involved lymph node(s) (pN+) between 2006 and 2017. Sections of pN+ were re-reviewed and classified as no, minor (≤2 mm), or major (>2 mm) ENE. Patterns of failure and survival were compared between the groups and stratified by adjuvant treatment. Multivariable (MVA) analysis assessed the value of adjuvant treatment for minor and major ENE. RESULTS: Total of 384 patients, 62 had minor and 114 had major ENE. Adjuvant CRT was delivered in 32(15%), 21(34%), and 45(39%) of patients with no, minor and major ENE, respectively. Patients with minor ENE had similar 5-year loco-regional control (LRC) and distant control (DC) but lower disease-free survival (DFS) (38% vs. 51%, p = 0·02) compared to patients with no ENE, while patients with major ENE had marginally lower LRC (59% vs 74%, p = 0·07), lower DC (58% vs 82%,p = 0·005) and DFS (13% vs. 38%, p=·001) compared to those with minor. On MVA, adjuvant chemotherapy was associated with improved DFS for major ENE (adjusted HR = 0·49; 95% CI 0·29-0·85, p = 0·01) but not for minor ENE after adjusting for age, ECOG status, T-, N-category, margin status, and radiotherapy. CONCLUSIONS:
Adjuvant chemoradiotherapy improves outcomes in patients with major ENE, but the benefit is unclear in patients with minor ENE. Future trials should focus on intensification of treatment for patients with major ENE and alternative adjuvant strategies for patients with minor ENE.
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Authors | John R de Almeida, Tra Truong, Nazir Mohemmed Khan, Jie Susie Su, Jonathan Irish, Ralph Gilbert, David Goldstein, Shao Hui Huang, Brian O'Sullivan, Ali Hosni, Andrew Hope, John Waldron, Aaron R Hansen, Anna Spreafico, Lillian L Siu, Bayardo Perez-Ordonez, Wei Xu, Ilan Weinreb |
Journal | Oral oncology
(Oral Oncol)
Vol. 110
Pg. 104845
(11 2020)
ISSN: 1879-0593 [Electronic] England |
PMID | 32615441
(Publication Type: Journal Article)
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Copyright | Copyright © 2020 Elsevier Ltd. All rights reserved. |
Topics |
- Carcinoma, Squamous Cell
(drug therapy, mortality, pathology)
- Chemoradiotherapy, Adjuvant
(methods)
- Female
- Humans
- Male
- Middle Aged
- Mouth Neoplasms
(drug therapy, mortality, pathology)
- Postoperative Period
- Survival Analysis
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