Abstract | BACKGROUND: OBJECTIVE: To present a series of HH presenting with CPP and DRE managed in the neurosurgery department at our center with an emphasis on the associated endocrine abnormalities. MATERIALS AND METHODS: A prospective observational study over a period of five years included 16 patients of HH. All patients were evaluated with 3 Tesla Magnetic Resonance Imaging (MRI) brain, complete hormonal workup including gonadotrophins, testosterone (males) and estradiol (females), and video-electroencephalography (VEEG) as a part of epilepsy workup. All these patients were evaluated with postoperative hormonal workup and repeat MRI brain if repeat surgery was contemplated. RESULTS: Among the 16 patients of HH, there were 11 male and 6 female children. All the patients presented with DRE with four of these had associated CPP. All the patients underwent robotic-guided radiofrequency ablation (RFA), with 75% seizure freedom following 1st RFA surgery. Three of the four patients with CPP achieved both clinical and biochemical normalization. One patient had just a marginal reduction in the serum gonadotrophins. One patient was reoperated twice and three underwent RFA thrice. CONCLUSION: The management of HH should be individualized with DRE taking the precedence requiring early surgery. A multidisciplinary approach is therefore recommended for a successful outcome.
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Authors | Ramesh S Doddamani, Manjari Tripathi, Raghu Samala, Mohit Agrawal, Bhargavi Ramanujam, Jitin Bajaj, Shabari Girishan, Madhavi Tripathi, C S Bal, Ajay Garg, P Sarat Chandra |
Journal | Neurology India
(Neurol India)
2020 May-Jun
Vol. 68
Issue Supplement
Pg. S146-S153
ISSN: 1998-4022 [Electronic] India |
PMID | 32611907
(Publication Type: Journal Article)
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Topics |
- Adolescent
- Child
- Child, Preschool
- Female
- Hamartoma
(complications, diagnostic imaging, surgery)
- Humans
- Hypothalamic Diseases
(complications, diagnostic imaging, surgery)
- Infant
- Magnetic Resonance Imaging
- Male
- Neurosurgical Procedures
(methods)
- Retrospective Studies
- Seizures
(diagnostic imaging, etiology, surgery)
- Treatment Outcome
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