Abstract | PURPOSE:
Immune checkpoint inhibitors (ICIs) have been approved for various types of cancer; however, they cause a broad spectrum of immune-related adverse events (irAEs). The association between the development of irAEs and the clinical benefit remains uncertain. We aimed to evaluate the association of irAEs and the treatment efficacy in real-world practice. PATIENTS AND METHODS: RESULTS: Of 212 patients eligible for this study, 108 experienced irAEs and 42 developed multiple irAEs. The median OS was significantly longer in the irAEs than in the no-irAE group (28.1 months vs 12.7 months; hazard ratio [HR], 0.49; 95% confidence interval [CI], 0.33-0.73; P = 0.0004). Moreover, the OS of patients with multiple irAEs was significantly longer than that of patients with a single irAE (42.3 months vs 18.8 months; HR, 0.473; 95% CI, 0.346-0.647; P < 0.0001). CONCLUSION: Our single-center retrospective study revealed a significant tendency associating the development of multiple irAEs with favorable prognoses.
|
Authors | Keitaro Shimozaki, Yasutaka Sukawa, Noriko Beppu, Isao Kurihara, Shigeaki Suzuki, Ryuichi Mizuno, Takeru Funakoshi, Shinnosuke Ikemura, Kai Tsugaru, Kazuhiro Togasaki, Kenta Kawasaki, Kenro Hirata, Hideyuki Hayashi, Yasuo Hamamoto, Hiromasa Takaishi, Takanori Kanai |
Journal | Cancer management and research
(Cancer Manag Res)
Vol. 12
Pg. 4585-4593
( 2020)
ISSN: 1179-1322 [Print] New Zealand |
PMID | 32606951
(Publication Type: Journal Article)
|
Copyright | © 2020 Shimozaki et al. |