Advances in Antimicrobial Microneedle Patches for Combating Infections.

Abstract

Skin infections caused by bacteria, viruses and fungi are difficult to treat by conventional topical administration because of poor drug penetration across the stratum corneum. This results in low bioavailability of drugs to the infection site, as well as the lack of prolonged release. Emerging antimicrobial transdermal and ocular microneedle patches have become promising medical devices for the delivery of various antibacterial, antifungal, and antiviral therapeutics. In the present review, skin anatomy and its barriers along with skin infection are discussed. Potential strategies for designing antimicrobial microneedles and their targeted therapy are outlined. Finally, biosensing microneedle patches associated with personalized drug therapy and selective toxicity toward specific microbial species are discussed.

• Authors: Rezvan Jamaledin, Cynthia K Y Yiu, Ehsan N Zare, Li-Na Niu, Raffaele Vecchione, Guojun Chen, Zhen Gu, Franklin R Tay, Pooyan Makvandi
• Journal: Advanced materials (Deerfield Beach, Fla.) (Adv Mater) Vol. 32 Issue 33 Pg. e2002129 (Aug 2020) ISSN: 1521-4095 [Electronic] Germany
• PMID: 32602146 (Publication Type: Journal Article, Review)
• Copyright: © 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Chemical References

• Anti-Infective Agents

Topics

• Animals
• Anti-Infective Agents (pharmacology, therapeutic use)
• Biosensing Techniques
• Humans
• Needles (microbiology)
• Skin Diseases (drug therapy, microbiology, virology)