Amdinocillin: interaction with other beta-lactam antibiotics for gram-negative bacteria.

Abstract

Amdinocillin was studied alone and in combination with three other beta-lactam antibiotics (aztreonam, cefoperazone, and ceftriaxone) for activity against gram-negative bacilli. These antibiotic combinations failed to show synergy by the checker-board double-dilution test or by killing kinetic studies. However, amdinocillin did show additive killing action when combined with the other beta-lactam antibiotics studied. Amdinocillin failed to induce or inhibit beta-lactamase production in species of Enterobacteriaceae, but with Pseudomonas aeruginosa, beta-lactamase production was induced. It is concluded that the activity of amdinocillin alone or in combination with another beta-lactam antibiotic should not be more effective in the treatment of infections by gram-negative bacilli than just using the beta-lactam antibiotic alone at a higher dose.

• Authors: R H Eng, R Liu, S M Smith, E S Johnson, C E Cherubin
• Journal: Chemotherapy (Chemotherapy) Vol. 34 Issue 1 Pg. 18-26 ( 1988) ISSN: 0009-3157 [Print] Switzerland
• PMID: 3258230 (Publication Type: Journal Article)

Chemical References

• Anti-Bacterial Agents
• beta-Lactamases
• Amdinocillin

Topics

• Amdinocillin (pharmacology)
• Anti-Bacterial Agents (pharmacology)
• Drug Synergism
• Gram-Negative Bacteria (drug effects, enzymology)
• Microbial Sensitivity Tests
• beta-Lactamases (biosynthesis)