Diagnosis and Resection Treatment of Triplet Hepatocellular Carcinomas with a non-B non-C Background in a Middle Aged Man over a Period of 6-years.

Abstract

We report a 71-year-old man with non-B non-C chronic liver damage who had been regularly visiting our hospital since he was 38 years of age. He underwent three partial hepatectomies for hepatocellular carcinoma (HCC) diagnosed at 65, 67, and 71 years of age, respectively. A histopathological examination showed moderately-differentiated HCC, and chronic hepatitis with mild fibrosis stage in non-tumor areas. alpha-fetoprotein (AFP) and PIVKAII were not useful for the early prediction of HCC, but TERT promotor mutation (C228T) in serum cell-free DNA was useful. This is the first report on the importance of long-term follow-up in non-B non-C chronic liver damage, regardless of the fibrosis stage.

• Authors: Akira Kajiwara, Keiichi Kinowaki, Norio Akuta, Kayoko Kasuya, Nozomu Muraishi, Soichi Iritani, Yusuke Kawamura, Shunichiro Fujiyama, Hitomi Sezaki, Tetsuya Hosaka, Satoshi Saitoh, Masahiro Kobayashi, Mariko Kobayashi, Yasuji Arase, Kenji Ikeda, Fumitaka Suzuki, Hiromitsu Kumada, Yoshiyuki Suzuki
• Journal: Internal medicine (Tokyo, Japan) (Intern Med) Vol. 59 Issue 20 Pg. 2511-2516 (Oct 15 2020) ISSN: 1349-7235 [Electronic] Japan
• PMID: 32581173 (Publication Type: Case Reports, Journal Article)

Chemical References

• AFP protein, human
• alpha-Fetoproteins

Topics

• Adult
• Aged
• Carcinoma, Hepatocellular (diagnosis, genetics, physiopathology, surgery)
• Follow-Up Studies
• Hepatectomy
• Humans
• Liver Function Tests (statistics & numerical data)
• Liver Neoplasms (diagnosis, genetics, physiopathology, surgery)
• Male
• Middle Aged
• Mutation
• Time and Motion Studies
• alpha-Fetoproteins (genetics)