Bacteriophage-Antibiotic Combinations for Enterococcus faecium with Varying Bacteriophage and Daptomycin Susceptibilities.

Abstract

Concerns regarding increased prevalence of daptomycin (DAP)-resistant strains necessitate novel therapies for Enterococcus faecium infections. Obligately lytic bacteriophages are viruses that target, infect, and kill bacterial cells. Limited studies have evaluated phage-antibiotic combinations against E. faecium After an initial screen of eight E. faecium strains, three strains with varying DAP/phage susceptibilities were selected for further experiments. Phage-to-strain specificity contributed to synergy with antibiotics by time-kill analyses and was associated with lower development of phage resistance.

• Authors: Taylor Morrisette, Katherine L Lev, Razieh Kebriaei, Jacinda C Abdul-Mutakabbir, Kyle C Stamper, Sandra Morales, Susan M Lehman, Gregory S Canfield, Breck A Duerkop, Cesar A Arias, Michael J Rybak
• Journal: Antimicrobial agents and chemotherapy (Antimicrob Agents Chemother) Vol. 64 Issue 9 (08 20 2020) ISSN: 1098-6596 [Electronic] United States
• PMID: 32571816 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2020 American Society for Microbiology.

Chemical References

• Anti-Bacterial Agents
• Daptomycin

Topics

• Anti-Bacterial Agents (pharmacology)
• Bacteriophages
• Daptomycin (pharmacology)
• Enterococcus faecium
• Gram-Positive Bacterial Infections (therapy)
• Humans
• Microbial Sensitivity Tests
• Phage Therapy