Abstract | BACKGROUND: The aim of this study was to determine the feasibility and outcomes of early surgical ligation in preterm neonates with hemodynamically significant patent ductus arteriosus (HSPDA) and to investigate predictors for surgical treatment after unsuccessful medical management. METHODS: Medical records from the neonatal intensive care unit of Hanyang University Seoul Hospital from January 2010 to December 2018 were retrospectively reviewed. 233 preterm neonates weighing less than 1500g with HSPDA were enrolled in our study. Of these preterm neonates, 134 underwent surgical ligation and were subdivided into the early ligation group (n = 49; within 10 days of age) and the late ligation group (n = 85; after 10 days of age). RESULTS: CONCLUSIONS: Early surgical ligation minimizes the adverse effects of HSPDA in predicted preterm neonates who subsequently require surgical treatment for PDA. This result suggests that in preterm neonates weighing less than 1500g with HSPDA that is unresponsive to medical treatment, delayed ductal closure should be avoided to reduce severe NEC, severe IVH, culture-proven sepsis, and facilitate earlier endotracheal extubation.
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Authors | Jun Ho Lee, Hyun Ju Lee, Hyun-Kyung Park, Ja-Hye Ahn, Hee Sun Kim, Hyo Jun Jang, Sun Kyun Ro, Hyuck Kim |
Journal | Journal of cardiothoracic surgery
(J Cardiothorac Surg)
Vol. 15
Issue 1
Pg. 144
(Jun 17 2020)
ISSN: 1749-8090 [Electronic] England |
PMID | 32552772
(Publication Type: Comparative Study, Journal Article)
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Topics |
- Cerebral Intraventricular Hemorrhage
(complications)
- Ductus Arteriosus, Patent
(surgery)
- Enterocolitis, Necrotizing
(complications)
- Feasibility Studies
- Female
- Gestational Age
- Hemodynamics
- Humans
- Hypertension, Pregnancy-Induced
- Incidence
- Infant, Low Birth Weight
- Infant, Newborn
- Infant, Premature
- Intensive Care, Neonatal
- Ligation
- Male
- Pregnancy
- ROC Curve
- Republic of Korea
- Retrospective Studies
- Risk Factors
- Sepsis
(complications)
- Tertiary Care Centers
- Treatment Outcome
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