X-ray induced photodynamic therapy (PDT) with a mitochondria-targeted liposome delivery system.

Abstract

In this study, we constructed multifunctional liposomes with preferentially mitochondria-targeted feature and gold nanoparticles-assisted synergistic photodynamic therapy. We systemically investigated the in vitro X-ray triggered PDT effect of these liposomes on HCT 116 cells including the levels of singlet oxygen, mitochondrial membrane potential, cell apoptosis/necrosis and the expression of apoptosis-related proteins. The results corroborated that synchronous action of PDT and X-ray radiation enhance the generation of cytotoxic reactive oxygen species produced from the engineered liposomes, causing mitochondrial dysfunction and increasing the levels of apoptosis.

• Authors: Xuefan Gu, Chao Shen, Hua Li, Ewa M Goldys, Wei Deng
• Journal: Journal of nanobiotechnology (J Nanobiotechnology) Vol. 18 Issue 1 Pg. 87 (Jun 10 2020) ISSN: 1477-3155 [Electronic] England
• PMID: 32522291 (Publication Type: Journal Article)

Chemical References

• Liposomes
• Singlet Oxygen
• Gold

Topics

• Apoptosis (drug effects)
• Gold (chemistry, metabolism, pharmacokinetics)
• HCT116 Cells
• Humans
• Liposomes (chemistry, pharmacokinetics, pharmacology)
• Membrane Potential, Mitochondrial (drug effects)
• Metal Nanoparticles (chemistry)
• Mitochondria (drug effects, metabolism, radiation effects)
• Photochemotherapy
• Singlet Oxygen (metabolism)
• X-Rays