Abstract | OBJECTIVES: In this study, we investigated the evolution of chronic pain in sickle cell patients (SCD) as an age-dependent phenomenon and studied the frequency of vaso-occlusive episode frequency, opioid use, quantitative sensory testing (QST), and biomarkers of chronic pain (CP). METHODS: We undertook a cross-sectional study of the evolution of CP in SCD. A total of 72 subjects (age 15-66) were enrolled. VOE frequency, presence of CP hydroxyurea (HU) therapy, opioid use, and laboratory parameters were collected. QST was performed, and plasma tryptase, substance P, and NGF ( Nerve Growth Factor) levels were assayed. RESULTS: There was an age-dependent increase in frequency of CP, VOEs, opioid use, and Von Frey monofilament values. CP patients had significantly higher opioid use (daily morphine equivalents) (52.8 mg vs 6.94 mg, P = .009), suggesting a correlation between opioid use and hyperalgesia. NGF levels were also significantly higher (P = .051). Our results confirm previous observations of an age-dependent increase in the proportion of patients with CP and support the contributing role of mast cell activation and neurogenic inflammation. CONCLUSIONS: This is the first study of NGF as a possible biomarker of CP in SCD. If confirmed, this could provide a diagnostic marker and therapeutic target for CP in SCD.
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Authors | Camila Albo, Sanjiv Kumar, Michael Pope, Kyle Michael Kidwell, Hongyan Xu, Latanya Bowman, Leigh Wells, Nadine Barrett, Sabine Fields, Pritam Bora, Niren Patel, Abdullah Kutlar |
Journal | European journal of haematology
(Eur J Haematol)
Vol. 105
Issue 4
Pg. 419-425
(Oct 2020)
ISSN: 1600-0609 [Electronic] England |
PMID | 32497305
(Publication Type: Journal Article)
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Copyright | © 2020 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. |
Chemical References |
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Topics |
- Acute Chest Syndrome
(diagnosis, etiology, therapy)
- Adolescent
- Adult
- Age Factors
- Aged
- Anemia, Sickle Cell
(complications, diagnosis, therapy)
- Biomarkers
- Chronic Pain
(diagnosis, etiology, therapy)
- Cross-Sectional Studies
- Female
- Humans
- Male
- Middle Aged
- Pain Management
- Pain Measurement
- Symptom Assessment
- Treatment Outcome
- Young Adult
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