Late leprosy reaction presenting as erythema multiforme-like erythema nodosum leprosum with underlying rifampicin resistance and its potential implications.

Abstract

Erythema multiforme (EM)-like erythema nodosum leprosum (ENL) is a rare atypical presentation, and its late appearance after the completion of multidrug therapy (MDT) is unusual. We describe the case of a lepromatous leprosy patient who after the completion of MDT presented to us with late EM-like ENL and was found to be resistant to rifampicin. We discuss the implications of this finding and the potential role of resistant bacilli in causing reactions with atypical presentations.

• Authors: Kabir Sardana, Anita Kulhari, Sinu Rose Mathachan, Ananta Khurana, Prekshi Bansal, Arvind Ahuja, Mallika Lavania, Madhvi Ahuja
• Journal: International journal of mycobacteriology (Int J Mycobacteriol) 2020 Apr-Jun Vol. 9 Issue 2 Pg. 226-228 ISSN: 2212-554X [Electronic] India
• PMID: 32474551 (Publication Type: Case Reports)

Chemical References

• Leprostatic Agents
• Rifampin

Topics

• Adult
• Drug Resistance, Bacterial (genetics)
• Drug Therapy, Combination (adverse effects)
• Erythema Multiforme (diagnosis, pathology)
• Erythema Nodosum (diagnosis, pathology)
• Humans
• Leprostatic Agents (therapeutic use)
• Leprosy (diagnosis, drug therapy)
• Male
• Mycobacterium lepraemurium (drug effects, genetics)
• Rifampin (pharmacology, therapeutic use)
• Time Factors