Abstract | BACKGROUND: METHODS: Adult patients with mild COA (Doppler peak velocity < 2.5 m/s) were matched 1:1 to patients without structural heart disease using propensity score method based on age, sex, body mass index, hypertension and blood pressure. The objective was to compare LV diastolic dysfunction (defined as E/e' > 2 standard deviations above age-specific normative values) between adults with repaired COA and controls. RESULTS: Of 204 COA and 204 control patients (age 35 ± 12 years), patients with COA had higher septal and lateral E/e' ratio (12 ± 4 vs 9 ± 4, p = 0.009) and (10 ± 3 vs 7 ± 3, p < 0.001), respectively. Compared to controls, the prevalence of LV diastolic dysfunction was higher in patients with COA for every age group: <40 years (63% vs 13%, p < 0.001); 41-60 years (87% vs 33%, p < 0.001); age > 60 years (82% vs 56%, p = 0.076). Left ventricular mass index (LVMI) was the strongest determinant of E/e' (β = 2.71 per 10 g/m2, standard error = 1.25, p < 0.001). CONCLUSION:
LV diastolic dysfunction was common in patients with COA, and the association with LVMI suggests that patients with COA may have ongoing LV pressure overload in the absence of hemodynamically significant re-coarctation.
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Authors | Alexander C Egbe, William R Miranda, Heidi M Connolly |
Journal | International journal of cardiology. Heart & vasculature
(Int J Cardiol Heart Vasc)
Vol. 28
Pg. 100530
(Jun 2020)
ISSN: 2352-9067 [Print] Ireland |
PMID | 32462075
(Publication Type: Journal Article)
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Copyright | © 2020 The Authors. |