Successful recovery from severe COVID-19 pneumonia after kidney transplantation: The interplay between immunosuppression and novel therapy including tocilizumab.

Abstract	Although immunosuppressed patients may be more prone to SARS-CoV-2 infection with atypical presentation, long-term immunosuppression therapy may provide some sort of protection for severe clinical complications of COVID-19. The interaction between immunosuppression and new antiviral drugs in the treatment of transplanted patients contracting COVID-19 has not yet been fully investigated. Moreover, data regarding the optimal management of these patients are still very limited. We report a case of the successful recovery from severe COVID-19 of a kidney-transplanted patient treated with hydroxychloroquine, lopinavir/ritonavir, steroid, and tocilizumab.
Authors	Andrea Lauterio, Mila Valsecchi, Sara Santambrogio, Riccardo De Carlis, Marco Merli, Angelo Calini, Leonardo Centonze, Vincenzo Buscemi, Maurizio Bottiroli, Massimo Puoti, Roberto Fumagalli, Luciano De Carlis
Journal	Transplant infectious disease : an official journal of the Transplantation Society (Transpl Infect Dis) Vol. 22 Issue 5 Pg. e13334 (Oct 2020) ISSN: 1399-3062 [Electronic] Denmark
PMID	32449235 (Publication Type: Case Reports, Journal Article)
Copyright	© 2020 Wiley Periodicals LLC.
Chemical References	Antibodies, Monoclonal, Humanized Antiviral Agents Heparin, Low-Molecular-Weight Immunosuppressive Agents Lopinavir Hydroxychloroquine Prednisolone tocilizumab Ritonavir
Topics	Antibodies, Monoclonal, Humanized (therapeutic use) Antiviral Agents (therapeutic use) COVID-19 (diagnosis, immunology, therapy, virology) Drug Therapy, Combination (methods) Female Graft Rejection (immunology, prevention & control) Heparin, Low-Molecular-Weight (therapeutic use) Humans Hydroxychloroquine (therapeutic use) Immunosuppression Therapy (adverse effects) Immunosuppressive Agents (adverse effects) Kidney Transplantation (adverse effects) Lopinavir (therapeutic use) Lung (diagnostic imaging) Middle Aged Prednisolone (therapeutic use) Respiration, Artificial Ritonavir (therapeutic use) SARS-CoV-2 (immunology, isolation & purification) Severity of Illness Index Tomography, X-Ray Computed Treatment Outcome

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