Angiotensin converting enzyme: A review on expression profile and its association with human disorders with special focus on SARS-CoV-2 infection.

Abstract

Angiotensin-converting enzyme (ACE) and its homologue, ACE2, have been mostly associated with hypertensive disorder. However, recent pandemia of SARS-CoV-2 has put these proteins at the center of attention, as this virus has been shown to exploit ACE2 protein to enter cells. Clear difference in the response of affected patients to this virus has urged researchers to find the molecular basis and pathophysiology of the cell response to this virus. Different levels of expression and function of ACE proteins, underlying disorders, consumption of certain medications and the existence of certain genomic variants within ACE genes are possible explanations for the observed difference in the response of individuals to the SARS-CoV-2 infection. In the current review, we discuss the putative mechanisms for this observation.

• Authors: Soudeh Ghafouri-Fard, Rezvan Noroozi, Mir Davood Omrani, Wojciech Branicki, Ewelina Pośpiech, Arezou Sayad, Krzysztof Pyrc, Paweł P Łabaj, Reza Vafaee, Mohammad Taheri, Marek Sanak
• Journal: Vascular pharmacology (Vascul Pharmacol) Vol. 130 Pg. 106680 (07 2020) ISSN: 1879-3649 [Electronic] United States
• PMID: 32423553 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
• Copyright: Copyright © 2020 Elsevier Inc. All rights reserved.

Chemical References

• ACE protein, human
• Peptidyl-Dipeptidase A

Topics

• COVID-19
• Coronavirus Infections (enzymology, genetics, pathology)
• Humans
• Pandemics
• Peptidyl-Dipeptidase A (biosynthesis, blood, genetics)
• Pneumonia, Viral (enzymology, genetics, pathology)