Novel Biomedical Functions of Surfactin A from Bacillus subtilis in Wound Healing Promotion and Scar Inhibition.

Abstract

Surfactin produced by Bacillus subtilis is a powerful biosurfactant in food, cosmetics, and pesticide industries. However, its suitability in wound healing applications is uncertain. In this article, we determined the effects of surfactin A from B. subtilis on wound healing, angiogenesis, cell migration, inflammatory response, and scar formation. The results indicated that 80.65 ± 2.03% of surfactin A-treated wounds were closed, whereas 44.30 ± 4.26% of the vehicle-treated wound areas remained open on day 7 (P < 0.05). In mechanisms, it upregulated the expression of hypoxia-inducible factor-1α (HIF-1α) and vascular endothelial growth factor (VEGF), accelerated keratinocyte migration through mitogen-activated protein kinase (MAPK) and nuclear factor-κB (NF-κB) signaling pathways, and regulated the secretion of proinflammatory cytokines and macrophage phenotypic switch. More attractive, surfactin A showed a seductive capability to inhibit scar tissue formation by affecting the expression of α-smooth muscle actin (α-SMA) and transforming growth factor (TGF-β). Overall, the study revealed a new function and potential of surfactin A as an affordable and efficient wound healing drug.

• Authors: Lu Yan, Guanwen Liu, Bin Zhao, Bing Pang, Wanqin Wu, Chongyang Ai, Xixi Zhao, Xinglong Wang, Chunmei Jiang, Dongyan Shao, Qianlong Liu, Meixuan Li, Lei Wang, Junling Shi
• Journal: Journal of agricultural and food chemistry (J Agric Food Chem) Vol. 68 Issue 26 Pg. 6987-6997 (Jul 01 2020) ISSN: 1520-5118 [Electronic] United States
• PMID: 32412748 (Publication Type: Journal Article)

Chemical References

• Hypoxia-Inducible Factor 1, alpha Subunit
• Lipopeptides
• NF-kappa B
• Transforming Growth Factor beta
• Vascular Endothelial Growth Factor A
• surfactin A

Topics

• Animals
• Bacillus subtilis (chemistry, metabolism)
• Cicatrix (drug therapy, genetics, metabolism, physiopathology)
• Humans
• Hypoxia-Inducible Factor 1, alpha Subunit (genetics, metabolism)
• Lipopeptides (metabolism, pharmacology)
• Male
• Mice
• NF-kappa B (genetics, metabolism)
• Transforming Growth Factor beta (metabolism)
• Vascular Endothelial Growth Factor A (genetics, metabolism)
• Wound Healing (drug effects)