Abstract | AIMS: METHODS AND RESULTS: Using Danish nationwide registers, we included Danish AF patients treated with OACs between 2001 and 2015. Non-parametric estimation and semi-parametric absolute risk regression were used to estimate the absolute risk of urinary tract cancer in patients with and without gross haematuria. We included 125 063 AF patients with a median age of 74 years (interquartile range 65-80) and a majority of males (57%). The absolute risk of gross haematuria 12 months after treatment initiation increased with age ranging from 0.37% [95% confidence interval (CI) 0.31-0.42] to 0.85% (95% CI 0.75-0.96) in the youngest and oldest age groups of ≤70 and >80 years of age, respectively. The 1-year risk of urinary tract cancer after haematuria ranged from 4.2% (95% CI 2.6-6.6) to 6.5% (95% CI 4.6-9.0) for patients in age group >80 and 71-80 years, respectively. Gross haematuria conferred large risk ratios of urinary tract cancer when comparing patients with and without haematuria across all age groups. CONCLUSION: Gross haematuria was associated with clinically relevant risks of urinary tract cancer in anticoagulated patients with AF. These findings underline the importance of meticulously examining anticoagulated patients with haematuria.
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Authors | Peter Vibe Rasmussen, Frederik Dalgaard, Gunnar Hilmar Gislason, Axel Brandes, Søren Paaske Johnsen, Erik Lerkevang Grove, Christian Torp-Pedersen, Anne-Marie Bloch Münster, Marie Schmidt Erikson, Jannik Langtved Pallisgaard, Paul Blanche, Morten Lock Hansen |
Journal | European heart journal. Cardiovascular pharmacotherapy
(Eur Heart J Cardiovasc Pharmacother)
Vol. 7
Issue 5
Pg. 373-379
(Sep 21 2021)
ISSN: 2055-6845 [Electronic] England |
PMID | 32369580
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Published on behalf of the European Society of Cardiology. © The Author(s) 2020. |
Chemical References |
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Topics |
- Administration, Oral
- Aged
- Aged, 80 and over
- Anticoagulants
- Atrial Fibrillation
(complications, diagnosis, drug therapy)
- Hematuria
(chemically induced, diagnosis, epidemiology)
- Humans
- Male
- Risk Factors
- Stroke
(epidemiology)
- Urologic Neoplasms
(chemically induced, complications, drug therapy)
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