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Piecing Together a Broken Tumor Suppressor Phosphatase for Cancer Therapy.

Abstract
Members of the PP2A family of serine/threonine phosphatases are important human tumor suppressor genes. Unlike most tumor suppressors, they are rarely mutated/deleted, but rather are impaired by "inhibitor proteins." Two papers in this issue of Cell show how some phenothiazine derivatives reactivate specific PP2A isozymes with potential benefit in cancer and other diseases.
AuthorsJukka Westermarck, Benjamin G Neel
JournalCell (Cell) Vol. 181 Issue 3 Pg. 514-517 (04 30 2020) ISSN: 1097-4172 [Electronic] United States
PMID32359434 (Publication Type: Journal Article, Comment)
CopyrightCopyright © 2020 Elsevier Inc. All rights reserved.
Chemical References
  • Protein Phosphatase 2
Topics
  • Genes, Tumor Suppressor
  • Humans
  • Neoplasms (drug therapy, genetics)
  • Protein Phosphatase 2 (genetics)

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