Abstract | BACKGROUND: METHODS: N = 190 dynamic [11C] meta-hydroxyephedrine (HED) PET scans were reviewed from the PAREPET trial in ischemic cardiomyopathy patients with reduced left ventricular ejection fraction(LVEF ≤ 35%). N = 12 scans were excluded due to non-diagnostic quality. N = 178 scans were analyzed using FlowQuant and Corridor4DM software, each by two observers. Test-retest scans from N = 20 patients with stable heart failure were utilized for test-retest analysis. Denervation scores were defined as extent × severity of relative uptake defects in LV regions with < 75% of maximal uptake. Results were evaluated using intraclass correlation coefficient (ICC) and Bland-Altman coefficient of repeatability (RPC). RESULTS: Inter-observer, inter-software, and test-retest ICC values were excellent (ICC = 94% to 99%) and measurement variability was small (RPC < 11%). Mean differences between observers ranged .2% to 1.1% for Corridor4DM (P = .28), FlowQuant (P < .001), and between software programs (P < .001). Kaplan-Meier analysis demonstrated HED scores from both programs were predictive of SCA. CONCLUSION: Inter-rater reliability for both analysis programs was excellent and test-retest repeatability was consistent. The minimal difference in scores between FlowQuant and Corridor4DM supports their use in future trials.
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Authors | Jean Z Wang, Jonathan B Moody, Nicole Kaps, Deron Britt, Aaryn Lavallee, Jennifer M Renaud, Jason G E Zelt, Kai Yi Wu, Rob S Beanlands, James A Fallavollita, John M Canty, Robert A deKemp |
Journal | Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology
(J Nucl Cardiol)
Vol. 28
Issue 6
Pg. 2745-2757
(12 2021)
ISSN: 1532-6551 [Electronic] United States |
PMID | 32347526
(Publication Type: Comparative Study, Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Copyright | © 2020. American Society of Nuclear Cardiology. |
Chemical References |
- Contrast Media
- 3-hydroxyephedrine
- Ephedrine
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Topics |
- Aged
- Cardiac Imaging Techniques
- Contrast Media
- Ephedrine
(analogs & derivatives)
- Female
- Heart
(innervation)
- Humans
- Male
- Middle Aged
- Observer Variation
- Positron-Emission Tomography
- Reproducibility of Results
- Retrospective Studies
- Software
- Surgery, Computer-Assisted
- Sympathectomy
(methods)
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