APOE ε4 Allele Is Associated with Elevated Levels of CSF VILIP-1 in Preclinical Alzheimer's Disease.

Abstract

OBJECTIVES:

Cerebrospinal fluid (CSF) visinin-like protein 1 (VILIP-1) has been suggested as a biomarker for neuron injury, which has been shown to have a important diagnostic value in symptomatic Alzheimer's disease (AD). The study purpose is investigating potential effects of apolipoprotein E (APOE) ε4 on CSF VILIP-1 levels among the preclinical AD.

METHODS:

A total of 110 subjects (including 43 APOE ε4 carriers and 67 ε4 non-carriers) were obtained from the Alzheimer's Disease Neuroimaging Initiative (ADNI) in the present study.

RESULTS:

The results showed that VILIP-1 concentrations in the CSF were statistically significantly increased in APOE ε4 carriers in comparison with non-carriers. Increased CSF VILIP-1 level was positively associated with the concentrations of both CSF-tau and P-tau levels.

CONCLUSIONS:

Our findings suggested that APOE ε4 might affect CSF VILIP-1 level in preclinical AD, indicating an important role of APOE ε4 in neuron injury leading to AD.

• Authors: Lijun Wang, Miao Zhang, Qian Wang, Xianguo Jiang, Kunyi Li, Jun Liu, Alzheimer’s Disease Neuroimaging Initiative
• Journal: Neuropsychiatric disease and treatment (Neuropsychiatr Dis Treat) Vol. 16 Pg. 923-931 ( 2020) ISSN: 1176-6328 [Print] New Zealand
• PMID: 32308396 (Publication Type: Journal Article)
• Copyright: © 2020 Wang et al.