[Effects of oral administration of ceftriaxone in early life on glucolipid metabolism of high fat diet-induced mice].

Abstract

OBJECTIVE:

This study aimed to explore whether exposure to ceftriaxone during early life could influences glucose and lipid metabolism of high fat diet-induced mice.

METHODS:

Total 48 of female BALB/c aged 2 week old were randomly divided into control group(treated with saline), antibiotic group(treated with100 mg/kg ceftriaxone), high-fat diet group(treated with saline) and combined action group(treated with 100 mg/kg ceftriaxone)(n=12), respectively to stop gavage 2 weeks later. Then high-fat diet group and combined action group were fed with high-fat diet for 12 weeks. Fasting blood glucose(FBG) and oral glucose tolerance test were conducted in the last week. Serum total cholesterol(TC), triglyceride(TG), high-density lipoprotein cholesterol(HDL-C), low-density lipoprotein cholesterol(LDL-C), fasting insulin, leptin and TG, TC in liver were also measured. Furthermore, homeostasis model assessment of insulin resistance(HOMA-IR) was calculated from FBG and insulin.

RESULTS:

Compared with normal chow diet, high-fat diet impaired oral glucose tolerance and increased the levels of abdominal adipose tissue, FBG, HOMA-IR, lips in serum and liver and leptin(P<0. 05). The oral administration of ceftriaxone in early life impaired oral glucose tolerance and increased the levels of abdominal adipose tissue, FBG and TG in liver(P<0. 05). In addition, early ceftriaxone intervention could enhance the impaired glucose tolerance, the increasing FBG, insulin resistance and liver lipids associated with high-fat diet(P<0. 05).

CONCLUSION:

Early ceftriaxone intervention not only significantly increases the level of abdominal adipose tissue, FBG, insulin resistance and liver lipids, but also enhances glycolipid metabolic disorders induced by high-fat diet. These result suggest that the exposure to antibiotics in the early life might increase the sensitivity of host animal to high fat diet induced abnormal glycolipid metabolism late.

• Authors: Weixin Zhou, Zhonghua Miao, Ruyue Cheng, Yating Luo, Xi Shen, Ming Li, Fang He
• Journal: Wei sheng yan jiu = Journal of hygiene research (Wei Sheng Yan Jiu) Vol. 49 Issue 1 Pg. 92-97 (Jan 2020) ISSN: 1000-8020 [Print] China
• PMID: 32290921 (Publication Type: Journal Article)

Chemical References

• Blood Glucose
• Glycolipids
• Insulin
• Ceftriaxone

Topics

• Administration, Oral
• Animals
• Blood Glucose
• Ceftriaxone (administration & dosage, adverse effects)
• Diet, High-Fat (adverse effects)
• Female
• Glycolipids (metabolism)
• Insulin (blood)
• Insulin Resistance
• Lipid Metabolism
• Mice
• Mice, Inbred BALB C
• Random Allocation