Baseline clinical features predict visual outcome in young patients with central retinal vein occlusion.

Abstract

PURPOSE:

To evaluate prognostic factors in young patients with central retinal vein occlusion (CRVO).

METHODS:

Retrospective case series. CRVO patients aged ≤ 50 and follow-up ≥ 6 months were enrolled. The best corrected visual acuity (BCVA) and central retinal thickness (CRT) at baseline, 3 months, 6 months, and last visit were documented. Severity of retinopathy was graded by comparing to standard photos. Prognostic factors associated with visual outcome at 6 months were evaluated by multiple linear regression models.

RESULTS:

A total of 73 eyes from 69 patients with mean age 37.6 ± 8.5 were enrolled. Forty-seven (68%) patients were male. The mean follow-up duration was 25.9 ± 23.0 months. LogMAR BCVA improved from 0.979 ± 0.785 at baseline to 0.594 ± 0.748 at the 6 months (p < 0.001) and CRT improved from 475 ± 222 μm to 299 ± 104 μm (p < 0.001). Forty-eight (66%) eyes required anti-vascular endothelial growth factor (anti-VEGF) treatment. The mean number of injections was 2.25 ± 1.41 in the first 6 months and 75% of eyes received ≦ 3 injections during the clinical course. The baseline BCVA (coefficient 0.518, p < 0.001), grade of retinal hemorrhage (coefficient 0.230, p = 0.006), grade of retinal venous engorgement (coefficient 0.238, p = 0.011), grade of optic disc edema (coefficient - 0.226, p = 0.005), and diabetes mellitus (coefficient 0.264, p = 0.047) were the independent factors associated with visual outcome at 6 months.

CONCLUSIONS:

Baseline clinical features are useful for the prediction of visual outcome at 6 months in young CRVO patients.

• Authors: Yeo-Yang Koh, Chi-Chun Lai, Wei-Chi Wu, Yih-Shiou Hwang, Kuan-Jen Chen, Nan-Kai Wang, Tun-Lu Chen, Jerry Chien-Chieh Huang, Laura Liu, Ling Yeung
• Journal: Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie (Graefes Arch Clin Exp Ophthalmol) Vol. 258 Issue 7 Pg. 1367-1377 (Jul 2020) ISSN: 1435-702X [Electronic] Germany
• PMID: 32281001 (Publication Type: Journal Article)

Chemical References

• Angiogenesis Inhibitors
• Vascular Endothelial Growth Factor A

Topics

• Adolescent
• Adult
• Angiogenesis Inhibitors (administration & dosage)
• Female
• Fluorescein Angiography (methods)
• Follow-Up Studies
• Fundus Oculi
• Humans
• Intravitreal Injections
• Male
• Middle Aged
• Retina (pathology)
• Retinal Vein Occlusion (diagnosis, drug therapy, physiopathology)
• Retrospective Studies
• Time Factors
• Tomography, Optical Coherence (methods)
• Treatment Outcome
• Vascular Endothelial Growth Factor A (antagonists & inhibitors)
• Visual Acuity
• Young Adult