Abstract | BACKGROUND: OBJECTIVES: The purpose of this study was to examine the sex-related risk of 5-year cardiovascular outcomes after PCI. METHODS: RESULTS: Among 32,877 patients, 9,141 (27.8%) were women. Women were older and had higher body mass index, more frequent hypertension and diabetes, and less frequent history of surgical or percutaneous revascularization compared with men. By angiographic core laboratory analysis, lesions in women had smaller reference vessel diameter and shorter lesion length. At 5 years, women had a higher unadjusted rate of MACE (18.9% vs. 17.7%; p = 0.003), all-cause death (10.4% vs. 8.7%; p = 0.0008), cardiac death (4.9% vs. 4.0%; p = 0.003) and ID-TLR (10.9% vs. 10.2%; p = 0.02) compared with men. By multivariable analysis, female sex was an independent predictor of MACE (hazard ratio [HR:]: 1.14; 95% confidence interval [CI:]: 1.01 to 1.30; p = 0.04) and ID-TLR (HR: 1.23; 95% CI: 1.05 to 1.44; p = 0.009) but not all-cause death (HR: 0.91; 95% CI: 0.75 to 1.09; p = 0.30) or cardiac death (HR: 0.97; 95% CI: 0.73 to 1.29; p = 0.85). CONCLUSIONS: In the present large-scale, individual patient data pooled analysis of contemporary PCI trials, women had a higher risk of MACE and ID-TLR compared with men at 5 years following PCI.
|
Authors | Ioanna Kosmidou, Martin B Leon, Yiran Zhang, Patrick W Serruys, Clemens von Birgelen, Pieter C Smits, Ori Ben-Yehuda, Björn Redfors, Mahesh V Madhavan, Akiko Maehara, Roxana Mehran, Gregg W Stone |
Journal | Journal of the American College of Cardiology
(J Am Coll Cardiol)
Vol. 75
Issue 14
Pg. 1631-1640
(04 14 2020)
ISSN: 1558-3597 [Electronic] United States |
PMID | 32273029
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
|
Copyright | Copyright © 2020 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved. |
Topics |
- Coronary Angiography
(methods, statistics & numerical data)
- Coronary Artery Disease
(diagnosis, physiopathology, surgery)
- Coronary Vessels
(diagnostic imaging)
- Female
- Heart Disease Risk Factors
- Humans
- Long Term Adverse Effects
(diagnosis, mortality)
- Male
- Middle Aged
- Outcome Assessment, Health Care
- Percutaneous Coronary Intervention
(adverse effects, methods)
- Risk Assessment
(methods)
- Risk Factors
- Severity of Illness Index
|