Abstract | BACKGROUND: METHODS: This single-center, prospective, observational study was conducted over 24 months. We administered CERA to 35 non-dialysis patients with hemoglobin (Hb) < 11 g/dL and examined the results of the serum diacron-reactive oxygen metabolite (dROMs) test for oxidative stress markers and biological antioxidant potential (BAP) test for antioxidant markers. We then examined the renoprotective effects of CERA and the responsiveness to CERA. RESULTS: Eighteen patients experienced renal events (doubling of serum creatinine levels, decreased estimated glomerular filtration rate to < 6.0 mL/min/1.73 m2, or initiation of renal replacement therapy), seventeen of which survived. Kaplan-Meier analysis showed that responsiveness to CERA during the initial 3-month treatment period was a good predictor of renal events. Moreover, a high response to CERA during the 3 months independently suppressed renal events (hazard ratio, 0.344). High BAP levels at baseline were significantly associated with high responsiveness to CERA during the initial 3-month treatment period. CONCLUSION: Responsiveness to CERA during the first 3 months was an important indicator of CKD progression. Moreover, BAP test results determined responsiveness to CERA. This is the first report to show how antioxidant levels can be a potential marker of CERA's ability to control anemia in CKD patients.
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Authors | Jun Ino, Eri Kasama, Mio Kodama, Takako Harada, Keitaro Sato, Hitoshi Eizumi, Youichiro Kawashima, Kosaku Nitta |
Journal | Clinical and experimental nephrology
(Clin Exp Nephrol)
Vol. 24
Issue 7
Pg. 590-597
(Jul 2020)
ISSN: 1437-7799 [Electronic] Japan |
PMID | 32185544
(Publication Type: Journal Article, Observational Study)
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Chemical References |
- Antioxidants
- Biomarkers
- Hematinics
- Hemoglobins
- Reactive Oxygen Species
- continuous erythropoietin receptor activator
- Erythropoietin
- Polyethylene Glycols
- Creatinine
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Topics |
- Aged
- Aged, 80 and over
- Anemia
(drug therapy, etiology)
- Antioxidants
(metabolism)
- Biomarkers
(blood)
- Creatinine
(blood)
- Disease Progression
- Erythropoietin
(administration & dosage, therapeutic use)
- Female
- Glomerular Filtration Rate
- Hematinics
(administration & dosage, therapeutic use)
- Hemoglobins
(metabolism)
- Humans
- Male
- Middle Aged
- Oxidative Stress
- Polyethylene Glycols
(administration & dosage, therapeutic use)
- Prognosis
- Prospective Studies
- Reactive Oxygen Species
(blood)
- Renal Insufficiency
(complications, physiopathology, therapy)
- Treatment Outcome
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