Abstract | BACKGROUND AND AIMS: MATERIAL AND METHODS: One hundred fifteen surgical patients under general anesthesia were randomised into three groups. All patients were given 2-3 mg/kg propofol and 1 μg/kg fentanyl intravenously for the induction of anesthesia followed by different doses of atracurium (0.6 mg/kg, 0.75 mg/kg or 1 mg/kg) without a priming dose. Tracheal intubation was performed within one minute after the administration of the study drugs. The intubating conditions, vocal cord movement and diaphragm movement were graded as the primary endpoints. Statistical analysis was done using one-way analysis of variance (ANOVA) and Post Hoc tests. RESULTS:
Atracurium doses of 1 mg/kg, 0.75 mg/kg, and 0.6 mg/kg provided 51.4%, 43.6% and 26.3% success rates of intubation without coughing or bucking, respectively (P = 0.03). The intubating conditions were graded as excellent or good in 86.5% of the 1 mg/kg atracurium group patients and in 84.6% of the 0.75 mg/kg group patients (P < 0.05). An atracurium dose of 1 mg/kg facilitated significant differences in vocal cord and diaphragm paralysis compared with the dose of 0.6 mg/kg (P = 0.03). CONCLUSION:
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Authors | Pornpan Chalermkitpanit, Oraluxna Rodanant, Winnie Thaveepunsan, Sireedhorn Assavanop |
Journal | Journal of anaesthesiology, clinical pharmacology
(J Anaesthesiol Clin Pharmacol)
2020 Jan-Mar
Vol. 36
Issue 1
Pg. 37-42
ISSN: 0970-9185 [Print] India |
PMID | 32174655
(Publication Type: Journal Article)
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Copyright | Copyright: © 2020 Journal of Anaesthesiology Clinical Pharmacology. |