Abstract | BACKGROUND AND OBJECTIVES: MATERIALS AND METHODS: Twenty-nine (29) individuals participated in the study, and they were assigned into 3 groups based on medical status and clinical periodontal examination; 9 patients with amlodipine-induced gingival overgrowth, 11 patients with inflammatory gingival overgrowth, and 9 healthy individuals as a control group. Clinical periodontal parameters including plaque index (PI), gingival index (GI), and gingival overgrowth index (GOI) were recorded. Blood and gingival crevicular fluid (GCF) samples were obtained. Gingival tissues were taken by appropriate periodontal surgery following initial periodontal therapy. To detect IL-17A on tissue samples, immunohistochemistry (IHC) was performed. Quantitative analysis was done, and the expression level of IL-17A was given as the percent positively stained cells. Enzyme-linked immunosorbent assay (ELISA) kits were used to analyze IL-17A in serum and GCF samples. RESULTS: All recorded clinical parameters were significantly higher in gingival overgrowth groups compared with control. Evaluation of inflammation on tissue sections did not show any significant change within the groups. Immunohistochemistry findings showed that IL-17A expression was increased in amlodipine samples (81.90%) compared with control samples (42.35%) (P < .001). There was an increase in the inflammatory group (66.08%) which is significantly less than the amlodipine group (P < .05). IL-17A levels in serum and GCF samples were not different within the study groups. CONCLUSION:
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Authors | Siddika Selva Sume, Ezel Berker, Yagmur Ilarslan, Ozlem Ozer Yucel, Cagman Tan, Samir Goyushov, Sibel E Gultekin, Ilhan Tezcan |
Journal | Journal of periodontal research
(J Periodontal Res)
Vol. 55
Issue 5
Pg. 613-621
(Oct 2020)
ISSN: 1600-0765 [Electronic] United States |
PMID | 32173874
(Publication Type: Journal Article)
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Copyright | © 2020 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. |
Chemical References |
- Antihypertensive Agents
- IL17A protein, human
- Interleukin-17
- Amlodipine
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Topics |
- Amlodipine
(adverse effects)
- Antihypertensive Agents
(adverse effects)
- Dental Plaque Index
- Gingival Crevicular Fluid
- Gingival Overgrowth
(chemically induced, genetics)
- Humans
- Interleukin-17
(metabolism)
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