Abstract | BACKGROUND: METHODS: RESULTS: All children had normal left ventricular (LV) systolic function as measured by LV fractional shortening and no heart failure. The end-diastolic septal thickness Z-scores (P < 0.01) and LV mass Z-scores (P < 0.01) were significantly smaller than normal for body-surface area in both sexes. The average LV mass Z-scores were significantly smaller for girls (P < 0.01) and marginally smaller for boys (P = 0.06). Girls had significantly smaller LV end-diastolic dimension Z-scores normalized to BSA (P < 0.01) compared to healthy controls and had significant increases in NT-proBNP. Four children developed SMNs as first events, a rate similar to historical controls. CONCLUSIONS: TRIAL REGISTRATIONS: ClinicalTrials.gov: NCT00003937 (P9754) registered 1 Nov 1999, and NCT00023998 (AOST0121) registered 13 Sept 2001.
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Authors | Lisa M Kopp, Richard B Womer, Cindy L Schwartz, David H Ebb, Vivian I Franco, David Hall, Donald A Barkauskas, Mark D Krailo, Holcombe E Grier, Paul A Meyers, Leonard H Wexler, Neyssa M Marina, Katherine A Janeway, Richard Gorlick, Mark L Bernstein, Steven E Lipshultz, Children’s Oncology Group |
Journal | Cardio-oncology (London, England)
(Cardiooncology)
Vol. 5
Pg. 15
( 2019)
ISSN: 2057-3804 [Electronic] England |
PMID | 32154021
(Publication Type: Journal Article)
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Copyright | © The Author(s). 2019. |