Impact of the Glycemic Control and Duration of Type 2 Diabetes on Vitamin D Level and Cardiovascular Disease Risk.

Abstract

BACKGROUND AND AIMS:

To investigate the impact of glycemic control and T2D duration on vitamin D status and cardiovascular disease (CVD) risk among Saudi patients.

METHODS:

This case-control study was conducted in King Faisal Specialist Hospital, Saudi Arabia. A total of 25 nondiabetic controls and 92 patients with confirmed T2D, aged 20-60 years, were included. Patients with T2D were divided into the following groups based on disease duration (newly diagnosed: ≈6 months and long duration: ≥5 years) and glycemic control based on their glycated hemoglobin (HbA1C) level with a threshold of ≤0.053 mol/mol: newly diagnosed controlled (NC, n = 25), newly diagnosed uncontrolled (NU, n = 25), newly diagnosed uncontrolled (NU, n = 25), newly diagnosed uncontrolled (NU, n = 25), newly diagnosed uncontrolled (NU.

RESULTS:

Our study showed that T2D duration was an independent predictor of vitamin D deficiency. The longer disease duration, the lower odds of being vitamin D deficient (odds ratio (OR) = 0.05, 95% CI: 0.01-0.29, p < 0.05). No significant association was observed between vitamin D and HbA1C levels. In the NU group, CVD risk scores were directly correlated with serum 25(OH)D (r = 0.53, p < 0.05). No significant association was observed between vitamin D and HbA1C levels. In the NU group, CVD risk scores were directly correlated with serum 25(OH)D (r = 0.53, p < 0.05). No significant association was observed between vitamin D and HbA1C levels. In the NU group, CVD risk scores were directly correlated with serum 25(OH)D (.

CONCLUSION:

Duration of diabetes rather than glycemic control is associated with vitamin D deficiency. Glycemic uncontrol may augment vitamin D deficiency-associated CVD risk in both newly diagnosed and old patients with type 2 diabetes.

• Authors: Thuraya A Alaidarous, Noura M Alkahtani, Ghadeer S Aljuraiban, Mahmoud M A Abulmeaty
• Journal: Journal of diabetes research (J Diabetes Res) Vol. 2020 Pg. 8431976 ( 2020) ISSN: 2314-6753 [Electronic] England
• PMID: 32149154 (Publication Type: Journal Article)
• Copyright: Copyright © 2020 Thuraya A. Alaidarous et al.

Chemical References

• Blood Glucose
• Glycated Hemoglobin A
• Vitamin D
• 25-hydroxyvitamin D

Topics

• Adult
• Blood Glucose
• Cardiovascular Diseases (complications)
• Case-Control Studies
• Diabetes Mellitus, Type 2 (blood, complications)
• Female
• Glycated Hemoglobin (metabolism)
• Humans
• Male
• Middle Aged
• Time Factors
• Vitamin D (analogs & derivatives, blood)
• Vitamin D Deficiency (blood, complications)
• Young Adult