Single-Pass vs 2-Pass Endoscopic Ultrasound-Guided Fine-Needle Biopsy Sample Collection for Creation of Pancreatic Adenocarcinoma Organoids.

Abstract

Pancreatic ductal adenocarcinoma (PDAC) has one of the poorest prognoses of all malignancies, with a 5-year survival rate <8%.1,2 Suspicious lesions are typically diagnosed via endoscopic ultrasound-guided fine-needle aspiration or endoscopic ultrasound-guided fine-needle biopsy (EUS-FNB).3 Fewer needle passes decreases the risk of postprocedure complications, including pancreatitis and hemorrhage, while allowing additional needle passes to be used for adjuvant tissue testing, such as organoid creation and DNA sequencing.

• Authors: Joseph F Lacomb, Dennis Plenker, Hervé Tiriac, Juan Carlos Bucobo, Lionel S D'souza, Asim S Khokhar, Hardik Patel, Breana Channer, Dimitri Joseph, Maoxin Wu, David A Tuveson, Ellen Li, Jonathan M Buscaglia
• Journal: Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association (Clin Gastroenterol Hepatol) Vol. 19 Issue 4 Pg. 845-847 (04 2021) ISSN: 1542-7714 [Electronic] United States
• PMID: 32119924 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2021 AGA Institute. Published by Elsevier Inc. All rights reserved.

Topics

• Adenocarcinoma (diagnosis)
• Endoscopic Ultrasound-Guided Fine Needle Aspiration (methods)
• Humans
• Organoids
• Pancreatic Neoplasms (diagnosis)