Roles of Splicing Factors in Hormone-Related Cancer Progression.

Abstract

Splicing of mRNA precursor (pre-mRNA) is a mechanism to generate multiple mRNA isoforms from a single pre-mRNA, and it plays an essential role in a variety of biological phenomena and diseases such as cancers. Previous studies have demonstrated that cancer-specific splicing events are involved in various aspects of cancers such as proliferation, migration and response to hormones, suggesting that splicing-targeting therapy can be promising as a new strategy for cancer treatment. In this review, we focus on the splicing regulation by RNA-binding proteins including Drosophila behavior/human splicing (DBHS) family proteins, serine/arginine-rich (SR) proteins and heterogeneous nuclear ribonucleoproteins (hnRNPs) in hormone-related cancers, such as breast and prostate cancers.

• Authors: Toshihiko Takeiwa, Yuichi Mitobe, Kazuhiro Ikeda, Kuniko Horie-Inoue, Satoshi Inoue
• Journal: International journal of molecular sciences (Int J Mol Sci) Vol. 21 Issue 5 (Feb 25 2020) ISSN: 1422-0067 [Electronic] Switzerland
• PMID: 32106418 (Publication Type: Journal Article, Review)

Chemical References

• Hormones
• RNA Splicing Factors

Topics

• Animals
• Breast Neoplasms (genetics, metabolism, pathology)
• Female
• Gene Expression Regulation, Neoplastic
• Hormones (metabolism)
• Humans
• Male
• Prostatic Neoplasms (genetics, metabolism, pathology)
• RNA Splicing Factors (genetics, metabolism)