New γ-pyrone glycoside from Pachira glabra and assessment of its gastroprotective activity using an alcohol-induced gastric ulcer model in rats.

Abstract

Pachira glabra is a medium sized tree that is famous for its delicious edible seeds and leaves. Phytochemical investigation of Pachira glabra leaf alcohol extract led to the isolation of a new γ-pyrone glycoside, 7-hydroxy maltol-3-O-β-d-glucoside (HMGlu). In vivo assessment of the gastro-protective activity of HMGlu demonstrated superior gastro-protection at a dose of 100 mg kg-1, close to the value triggered by the standard reference omeprazole drug (evidenced by morphological and histopathological examinations). This was further confirmed by immunohistochemical staining where pretreatment with HMGlu (100 mg kg-1) markedly reduced NFκB, COX-2 and BAX positively-stained cells. Thus, it can be concluded that 7-hydroxy maltol-3-O-β-d-glucoside can be a new pharmaceutically active agent with promising gastro-protective activity of natural origin.

• Authors: Mariam I Gamal El-Din, Fadia S Youssef, Mohamed L Ashour, Omayma A Eldahshan, Abdel Nasser B Singab
• Journal: Food & function (Food Funct) Vol. 11 Issue 3 Pg. 1958-1965 (Mar 26 2020) ISSN: 2042-650X [Electronic] England
• PMID: 32091511 (Publication Type: Journal Article)

Chemical References

• Anti-Ulcer Agents
• Glycosides
• Plant Extracts
• Ethanol

Topics

• Animals
• Anti-Ulcer Agents (pharmacology, therapeutic use)
• Bombacaceae
• Disease Models, Animal
• Ethanol
• Gastric Mucosa (drug effects)
• Glycosides (pharmacology, therapeutic use)
• Male
• Plant Extracts (pharmacology, therapeutic use)
• Rats
• Rats, Wistar
• Stomach Ulcer (chemically induced, prevention & control)