Abstract | OBJECTIVE: Impaired fasting glucose (IFG) and impaired glucose tolerance (IGT) may convey disparate risks of metabolic consequences. Fasting plasma glucose (FPG), while an expedient screening procedure, may not adequately assess metabolic risk, particularly among youths. In order to inform a strategy for screening Chinese youth for pre-diabetes, we examined the relative value of IFG versus IGT to define metabolic risk by assessing their association with insulin resistance, beta-cell dysfunction, adverse adipokine profiles and other cardiometabolic risk factors. RESEARCH DESIGN AND METHODS: We recruited 542 subjects (age 14-28 years) from the Beijing Child and Adolescent Metabolic Syndrome study for an in-depth assessment of cardiometabolic risk factors, including a 2-hour oral glucose tolerance test, liver ultrasound and serum levels of four adipokines. RESULTS: CONCLUSIONS: Chinese youth with iIGT exhibit a higher cardiometabolic risk profile than those with iIFG. Thus, 2 h PG is preferred over FPG to identify the pre-diabetes phenotype at greatest risk of subsequent development of cardiovascular disease. TRIAL REGISTRATION NUMBER: NCT03421444.
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Authors | Yu Li, Dan Feng, Issy C Esangbedo, Yanglu Zhao, Lanwen Han, Yingna Zhu, Junling Fu, Ge Li, Dongmei Wang, Yonghui Wang, Ming Li, Shan Gao, Steven M Willi |
Journal | BMJ open diabetes research & care
(BMJ Open Diabetes Res Care)
Vol. 8
Issue 1
(02 2020)
ISSN: 2052-4897 [Electronic] England |
PMID | 32049638
(Publication Type: Journal Article)
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Copyright | © Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. |
Chemical References |
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Topics |
- Adipokines
(blood)
- Adolescent
- Adult
- Beijing
(epidemiology)
- Blood Glucose
(analysis)
- Cardiometabolic Risk Factors
- Cross-Sectional Studies
- Fasting
(blood)
- Female
- Glucose Intolerance
(blood)
- Glucose Tolerance Test
- Humans
- Insulin-Secreting Cells
(metabolism, pathology)
- Longitudinal Studies
- Male
- Metabolic Syndrome
(blood, epidemiology)
- Prediabetic State
(blood, epidemiology)
- Young Adult
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