HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Peptidoglycan Recognition Proteins (PGRPs) Modulates Mosquito Resistance to Fungal Entomopathogens in a Fungal-Strain Specific Manner.

Abstract
Fungal entomopathogens are potential tools for the control of mosquito vectors that transmit infectious agents that cause disease in humans and animals. During the infection process, effective recognition of the invading fungi by the mosquito, is a crucial step in mounting an appropriate anti-fungal response. In this study, we investigated the role of peptidoglycan recognition receptors (PGRPs) in host resistance to fungal entomopathogens at the early stages of infection. Our study identified the induction of PGRP-LA, -LB, -LD, -LE, and -S1 during infection with two different fungal entomopathogenic strains. Furthermore, our data shows temporal differences in PGRP elicitation, with most PGRPs displaying significant upregulation at 60 h post-infection. Depletion of certain PGRPs via RNAi silencing resulted in a significant increase in fungal proliferation and a reduction in mosquito survival that was fungal strain-specific. Our data indicates that PGRPs play an important role in the antifungal response and expands our understanding of the factors that determine host susceptibility to fungal entomopathogens.
AuthorsJosé L Ramirez, Ephantus J Muturi, Lina B Flor-Weiler, Karl Vermillion, Alejandro P Rooney
JournalFrontiers in cellular and infection microbiology (Front Cell Infect Microbiol) Vol. 9 Pg. 465 ( 2019) ISSN: 2235-2988 [Electronic] Switzerland
PMID32039046 (Publication Type: Journal Article)
CopyrightCopyright © 2020 Ramirez, Muturi, Flor-Weiler, Vermillion and Rooney.
Chemical References
  • Carrier Proteins
  • Insect Proteins
  • peptidoglycan recognition protein
Topics
  • Aedes (genetics, immunology, microbiology)
  • Animals
  • Carrier Proteins (genetics, metabolism)
  • Culicidae (genetics, immunology, microbiology)
  • Disease Resistance (genetics, physiology)
  • Drosophila
  • Female
  • Fungi (metabolism, pathogenicity)
  • Gene Expression
  • Gene Knockdown Techniques
  • Gene Silencing
  • Immunity
  • Insect Proteins (metabolism)
  • RNA Interference
  • Transcriptome
  • Up-Regulation

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: