Bacterial infection is the main cause of implantation failure worldwide, and the importance of
antibiotics on medical devices has been undermined because of antibiotic resistance. Antimicrobial
hydrogels have emerged as a promising approach to combat
infections associated with medical devices and wound healing. However,
hydrogel coatings that simultaneously possess both antifouling and antimicrobial attributes are scarce. Herein, we report an antimicrobial
hydrogel that incorporates adhesion-inhibiting
polyethylene glycol (PEG) and colony-suppressing
chitosan (CS) as a dressing to combat
bacterial infections. These two
polymers have important environmentally benign characteristics including low toxicity, low volatility, and biocompatibility. Although
hydrogels containing PEG and CS have been reported for applications in the fields of
wound dressing, tissue repair, water purification, drug delivery, and scaffolds for bone regeneration, there still has been no report on the application of CS/PEG
hydrogel coatings in dental applications. Herein, this biointerface shows superior activity in early-stage adhesion inhibition (98.8%, 5 h) and displays remarkably long-lasting colony-suppression activity (93.3%, 7 d). Thus, this novel nanomaterial, which has potential as a dual-functional platform with integrated antifouling and antimicrobial functions with excellent biocompatibility, might be used as a safe and effective antimicrobial coating in biomedical device applications.